Gene
slc40a1
- ID
- ZDB-GENE-000511-8
- Name
- solute carrier family 40 member 1
- Symbol
- slc40a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits iron ion transmembrane transporter activity. Involved in several processes, including bone mineralization; hemoglobin biosynthetic process; and hemopoiesis. Predicted to localize to basolateral plasma membrane and integral component of membrane. Used to study iron deficiency anemia. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Is expressed in digestive system; gill; nervous system; solid lens vesicle; and yolk syncytial layer. Orthologous to human SLC40A1 (solute carrier family 40 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1041 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hemochromatosis type 4 | Alliance | Hemochromatosis, type 4 | 606069 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| iron deficiency anemia | slc40a1tp85c/tp85c | standard conditions | Bo et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ferroportin-1 | MFS transporter superfamily |
|---|---|---|---|
|
UniProtKB:Q9I9R3
|
562 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000003995 (1) | Havana | 3,749 nt | ||
| mRNA | ottdart00000004045 (1) | Havana | 2,763 nt | ||
| mRNA |
slc40a1-201
(1)
|
Ensembl | 3,780 nt |
Interactions and Pathways
No data available
Plasmids
No data available