Gene
slc40a1
- ID
- ZDB-GENE-000511-8
- Name
- solute carrier family 40 member 1
- Symbol
- slc40a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables iron ion transmembrane transporter activity. Acts upstream of or within several processes, including hemoglobin biosynthetic process; hemopoiesis; and response to copper ion. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in digestive system; gill; nervous system; solid lens vesicle; and yolk syncytial layer. Used to study iron deficiency anemia. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1041 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029605Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14190 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41502 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| slc40a1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| th238 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tp85c | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hemochromatosis type 4 | Alliance | Hemochromatosis, type 4 | 606069 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| iron deficiency anemia | slc40a1tp85c/tp85c | standard conditions | Bo et al., 2016 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ferroportin-1 | MFS transporter superfamily |
|---|---|---|---|---|
| UniProtKB:Q9I9R3 | InterPro | 562 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000003995 (1) | Havana | 3,749 nt | ||
| mRNA | ottdart00000004045 (1) | Havana | 2,763 nt | ||
| mRNA |
slc40a1-201
(1)
|
Ensembl | 3,780 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-204G5 | ZFIN Curated Data | |
| Contained in | BAC | XX-113D7 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-46I22 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-182H3 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-211O13 | ZFIN Curated Data | |
| Encodes | EST | eu1041 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:195301 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131629 (1) | 3773 nt | ||
| Genomic | GenBank:CT737230 (1) | 122646 nt | ||
| Polypeptide | UniProtKB:Q9I9R3 (1) | 562 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Yueyue, F., Qin, W., Jigang, L., Ouyang, L., Hu, Q., Chen, L. (2023) New insights into the antimicrobial mechanism of LEAP2 mutant zebrafish under Aeromonas hydrophila infection using transcriptome analysis. Fish & shellfish immunology. 143:109225
- Wattrus, S.J., Smith, M.L., Rodrigues, C.P., Hagedorn, E.J., Kim, J.W., Budnik, B., Zon, L.I. (2022) Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science (New York, N.Y.). 377:1413-1419
- Xi, J., Zhang, Z., Wang, Z., Wu, Q., He, Y., Xu, Y., Ding, Z., Zhao, H., Da, H., Zhang, F., Zhao, H., Fang, J. (2022) Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Free radical biology & medicine. 190:202-215
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Chandrapalan, T., Kwong, R.W.M. (2020) Influence of dietary iron exposure on trace metal homeostasis and expression of metal transporters during development in zebrafish☆. Environmental pollution (Barking, Essex : 1987). 261:114159
- Hassan, A.T., Kwong, R.W.M. (2020) The neurophysiological effects of iron in early life stages of zebrafish. Environmental pollution (Barking, Essex : 1987). 267:115625
- Camiolo, G., Tibullo, D., Giallongo, C., Romano, A., Parrinello, N.L., Musumeci, G., Di Rosa, M., Vicario, N., Brundo, M.V., Amenta, F., Ferrante, M., Copat, C., Avola, R., Li Volti, G., Salvaggio, A., Di Raimondo, F., Palumbo, G.A. (2019) α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload. International Journal of Molecular Sciences. 20(3):
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