Gene
stx1b
- ID
- ZDB-GENE-000330-4
- Name
- syntaxin 1B
- Symbol
- stx1b Nomenclature History
- Previous Names
-
- fb76h10
- syntaxin1b
- wu:fb76h10
- zgc:92909
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in protein transport; vesicle docking; and vesicle fusion. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system and plasma membrane. Is expressed in nervous system and trigeminal placode. Used to study epilepsy. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92909 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| generalized epilepsy with febrile seizures plus 9 | Alliance | Generalized epilepsy with febrile seizures plus, type 9 | 616172 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy | AB + MO1-stx1b | standard conditions | Hunyadi et al., 2017 |
| epilepsy | AB + MO1-stx1b + MO2-stx1b | standard conditions | Schubert et al., 2014 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SNARE | Syntaxin | Syntaxin/epimorphin, conserved site | Syntaxin, N-terminal domain | Target SNARE coiled-coil homology domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9I9P6 | InterPro | 288 |
Interactions and Pathways
No data available
Plasmids
No data available