Gene
stx1b
- ID
- ZDB-GENE-000330-4
- Name
- syntaxin 1B
- Symbol
- stx1b Nomenclature History
- Previous Names
-
- fb76h10
- syntaxin1b
- wu:fb76h10
- zgc:92909
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have SNAP receptor activity and SNARE binding activity. Involved in regulation of synaptic activity. Predicted to localize to several cellular components, including SNARE complex; endomembrane system; and integral component of membrane. Used to study epilepsy. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Is expressed in nervous system and trigeminal placode. Orthologous to human STX1B (syntaxin 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92909 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| generalized epilepsy with febrile seizures plus 9 | Alliance | Generalized epilepsy with febrile seizures plus, type 9 | 616172 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy | AB + MO1-stx1b | standard conditions | Hunyadi et al., 2017 |
| epilepsy | AB + MO1-stx1b + MO2-stx1b | standard conditions | Schubert et al., 2014 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | SNARE | Syntaxin | Syntaxin/epimorphin, conserved site | Syntaxin, N-terminal domain | Target SNARE coiled-coil homology domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9I9P6
|
288 |
Interactions and Pathways
No data available
Plasmids
No data available