notch2

ID

ZDB-GENE-000329-4

Name

notch receptor 2

Symbol

notch2 Nomenclature History

Previous Names

notch6
sb:cb884

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable Notch binding activity. Acts upstream of or within several processes, including face morphogenesis; lymphangiogenesis; and pancreas regeneration. Predicted to be located in nucleus and plasma membrane. Predicted to be part of receptor complex. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin; and splanchnocranium. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

42 figures from 31 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb884 (11 images)
eu314 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With notch2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Alagille syndrome	Alliance	Alagille syndrome 2	610205
Hajdu-Cheney syndrome	Alliance	Hajdu-Cheney syndrome	102500

Associated With notch2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000800	Notch domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR010660	Notch, NOD domain
Domain	IPR011656	Notch, NODP domain
Domain	IPR024600	Notch, C-terminal
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR008297	Notch
Family	IPR022336	Neurogenic locus notch homolog protein 2
Family	IPR051355	Notch and Slit guidance protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR035993	Notch-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR002110	Ankyrin repeat