ZFIN ID: ZDB-GENE-000322-3
Gene Name: troponin T type 3a (skeletal, fast)
Gene Symbol: tnnt3a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to contribute to calcium-dependent ATPase activity and tropomyosin binding activity. Involved in sarcomere organization. Predicted to localize to troponin complex. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type).
Genome Resources: Alliance (1),  Gene:58084 (1),  Ensembl(GRCz11):ENSDARG00000030270 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [MGC:64197]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24709 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ws01961aTg Transgenic Insertion Exon 6 Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tnnt3a N/A 1
    DISEASE ASSOCIATED WITH tnnt3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    distal arthrogryposis type 2B2 Alliance Arthrogryposis, distal, type 2B2 618435
    DISEASE ASSOCIATED WITH tnnt3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sarcomere organization (more)
    Cellular Component troponin complex (more)
    Molecular Function CONTRIBUTES_TO   calcium-dependent ATPase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnnt3a-201 (1)    Ensembl 1138
    ncRNA tnnt3a-002 (1)    Ensembl 370
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnnt3a No data available
    MARKER RELATIONSHIPS
    tnnt3a Contained in: [BAC] CH211-201M7 (1)
    tnnt3a Encodes: [cDNA] MGC:64197 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131565 (1) 1098 nt
    Genomic GenBank:BX004812 (1) 189554 nt
    Select Tool
    Polypeptide UniProtKB:Q9I8U9 (1) 230 aa
    Sequence Information (all 14)
    ORTHOLOGY for tnnt3a ( Chr: 25 )
    CITATIONS (33)