Gene
urod
- ID
- ZDB-GENE-000208-18
- Name
- uroporphyrinogen decarboxylase
- Symbol
- urod Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables uroporphyrinogen decarboxylase activity. Acts upstream of or within porphyrin-containing compound metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in blood; intermediate cell mass of mesoderm; kidney; and presumptive blood. Used to study hepatoerythropoietic porphyria. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| porphyria cutanea tarda | Alliance | Porphyria cutanea tarda | 176100 |
| porphyria cutanea tarda | Alliance | Porphyria, hepatoerythropoietic | 176100 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hepatoerythropoietic porphyria | urodtp61/tp61 | standard conditions | (2) |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | UROD/MetE-like superfamily | Uroporphyrinogen decarboxylase HemE | Uroporphyrinogen decarboxylase (URO-D) |
|---|---|---|---|---|---|
| UniProtKB:Q9PTS2 | InterPro | 369 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gata1a:urod-GFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-38P6 | ZFIN Curated Data | |
| Contains | STS | unp1690 | ||
| Encodes | EST | fc43e09 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:123153 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131347 (1) | 1414 nt | ||
| Genomic | GenBank:CU571330 (1) | 133116 nt | ||
| Polypeptide | UniProtKB:Q9PTS2 (1) | 369 aa |
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Lawson, N.D., Li, R., Shin, M., Grosse, A., Yukselen, O., Stone, O.A., Kucukural, A., Zhu, L. (2020) An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. eLIFE. 9:
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Zhang, Y., Qin, W., Lu, X., Xu, J., Huang, H., Bai, H., Li, S., Lin, S. (2017) Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. Nature communications. 8:118
- Feng, Y., Chen, C., Han, Y., Chen, Z., Lu, X., Liang, F., Li, S., Qin, W., Lin, S. (2016) Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9. G3 (Bethesda). 6(8):2517-21
- Huang, G., Zhang, F., Ye, Q., Wang, H. (2016) The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Autophagy. 12(8):1292-309
- Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
- Ablain, J., Durand, E.M., Yang, S., Zhou, Y., Zon, L.I. (2015) A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish. Developmental Cell. 32(6):756-64
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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