ZFIN is now using GRCz12tu for Genomic Data
Gene
igfbp2a
- ID
- ZDB-GENE-000125-12
- Name
- insulin-like growth factor binding protein 2a
- Symbol
- igfbp2a Nomenclature History
- Previous Names
-
- IGFBP-2
- igfbp2 (1)
- igfbp2b
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including negative regulation of DNA replication; negative regulation of developmental growth; and regulation of insulin-like growth factor receptor signaling pathway. Acts upstream of or within angiogenesis and heart development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including gonad; head; immature eye; nervous system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65741 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017891 | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site |
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Family | IPR012210 | Insulin-like growth factor binding protein 2 |
| Family | IPR022321 | Insulin-like growth factor-binding protein family 1-6, chordata |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor binding protein 2 | Insulin-like growth factor-binding protein family 1-6, chordata | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PTH3 | InterPro | 276 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfbp2a-201
(1)
|
Ensembl | 1,748 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers