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Fig. 4

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ZDB-FIG-260805-82

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Song et al., 2026 - Formononetin attenuates glucocorticoid-induced osteoporosis via multiple osteoimmunological pathways: evidence from zebrafish and network pharmacology

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Fig. 4

FMN-osteoporosis core target screening and PPI network construction based on network pharmacology. (A) Venn diagram analysis of FMN and osteoporosis (OP) shared targets; (B) Protein–protein interaction (PPI) network of the shared targets, with node size representing degree value; the larger and darker the node, the stronger its central role in the network; (C) GO functional annotation analysis, including Biological Process (BP), Cellular Component (CC), and Molecular Function (MF); (D) Bubble chart of key signaling pathway enrichment (sorted by enrichment value); (E) Relationship networks between target and KEGG pathways, sorted by frequency; (F) Top 10 key target genes, ranked by frequency in KEGG enrichment analysis. (G) Venn diagram for Core target visulization, based on the frequency of target occurrence in KEGG enriched pathways and the degree values in the protein–protein interaction (PPI) network

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Acknowledgments

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