FIGURE

Figure 2

ID

ZDB-FIG-260118-12

Publication

Stringer et al., 2025 - Clinical relevance of zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA

Other Figures

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Figure 2

Comparison of wild-type, 855VUS, and 861VUS SMN1 nucleotide and amino acid sequences.

The three panels show the nucleotide sequence of the coding strand of the wild-type (WT), 855VUS and 861VUS SMN1 alleles, from the first nucleotide of the final coding exon to the position of the stop codon. The 3’ amino acid sequence of the wild-type SMN protein is shown in blue, with changes associated with each VUS in red. The location of coding sequence nucleotides 855 and 861 and amino acid 288 are highlighted in the wild-type strand/sequence, and deletions are marked with dots.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.