FIGURE

Figure 3

ID

ZDB-FIG-251225-80

Publication

Colin et al., 2025 - MMS22L is a novel key actor of normal and pathological erythropoiesis

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Figure 3

scRNAseq dissects lineage‐specific consequences of MMS22L loss during hematopoietic differentiation. (A) Annotated two‐dimensional Uniform Manifold Approximation and Projection (UMAP) of our combined metacell (MCs) manifold comprising 70,657 single‐cell transcriptomes (36,007 shCTRL and 34,650 shMMS22L) collected at Day 0 and Day 7 of in vitro differentiation. MCs are shown as color‐coded points. The MC model was built based on the transcription profile of each MCs at the different time points, and annotation was performed based on known markers. BEMPS, basophils‐mast‐eosinophils progenitors; GMP, granulocyte‐monocyte progenitor; MEP, megakaryocyte erythroid progenitor; Mo/DCs, monocyte/dendritic cells; MK, megakaryocytes. (B) Combined MC model of in vitro differentiation with color intensity indicating the fraction of shMMS22L‐derived cells within each MC. (C) Stacked bar plots showing the cell type composition of shCTRL and shMMS22L transduced primary cells at Day 0 and Day 7 of differentiation, based on metacell models generated separately for each sample (see Supporting Information S1: Figure 6A for individual models).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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