Fig. 3
- ID
- ZDB-FIG-250916-54
- Publication
- Nair et al., 2025 - Human vaginal Lactobacillus Jensenii -derived (-)-Terpinen-4-ol restores antibiotic sensitivity by inhibiting efflux pumps in drug resistant E. coli and K. pneumoniae
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Membrane permeability of MDRK. pneumoniae and E. coli UTI89 is enhanced by (-)-Terpinen-4-ol treatment. Mid-log K. pneumoniae MTCC 432/BC1415 and E. coli UTI89 were treated with either erythromycin (Ery) or (-)-Terpinen-4-ol (Ltr- Lactobacillus derived and Tr- Commercially procured) or in combination (Ltr/Tr + Ery) along with fluorescent dye N-Phenyl 1-Naphthylamine (NPN) and fluorescence intensity was measured using a spectrofluorometer. NPN uptake factor was calculated as the ratio of background subtracted fluorescence of different groups to that of buffer. CTAB (cetyltrimethylammonium bromide) is used as a positive control (Unpaired t-test, n = 3, 95% CI, p*** < 0.0001). |