FIGURE

Fig. 4

ID

ZDB-FIG-250804-96

Publication

Gao et al., 2025 - Analysis of biased allelic enhancer activity of schizophrenia-linked common variants

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

SNP rs13072690 functions as a biased allelic enhancer regulating PCCB expression.A This diagram illustrates how the biased allelic enhancer SNP (rs13072690) potentially regulates the expression of the distant gene PCCB. The aggregated single-cell ATAC-seq (scATAC-seq) tracks display chromatin accessibility signals from all cells of the specified cell type, while Hi-C loop data derived from microglia cells show the physical interactions between rs13072690 and the PCCB promoter. B Results from the dual-luciferase reporter assay demonstrate the biased allelic enhancer activity of rs13072690, confirming its functional impact on gene regulation. Bars represent the mean ± SEM. C A comparison of brain tissue eQTLs from GTEx (V8) shows the association between rs13072690 and PCCB expression across various brain regions.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Commun Biol