FIGURE

Fig. 2

ID

ZDB-FIG-250627-25

Publication

Gomes et al., 2025 - Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection

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Fig. 2

Shigella-trained macrophages shift to a pro-inflammatory state (A) Representative images from the CHT region (top, white box indicates area imaged) of macrophages (magenta) expressing TNF-α (green) in naive (PBS, left) and Shigella-trained (right) larvae at 48 hp1i. Scale bar: 100 μm. Scale bars in insets: 10 μm. (B) Quantification of tnfa:GFP expression. (C) Quantification of H3K4me1 (left) and H3K4me3 (right) deposition in macrophages from naive (black) and Shigella-trained (green) larvae at 48 hp1i. Data were pooled from 3 independent experiments, with >20 larvae per experiment. ∗∗p < 0.01 and ∗∗∗∗p < 0.0001. (B and C) Student’s unpaired t test. Percentages indicate population with normalized values ≥ 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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