FIGURE

Fig 4

ID

ZDB-FIG-250505-104

Publication

Orlandi et al., 2025 - Zebrafish do not have a calprotectin ortholog

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Fig 4

Zebrafish s100s do not exhibit the pro-inflammatory characteristics of S100A9.

The bar graph shows relative activation of human and zebrafish TLR4 complexes in the presence of 1 μM zebrafish s100 proteins. The positive controls for this experiment included human TLR4 and zebrafish Tlr4ba treated with endotoxin (blue, outlined), and human TLR4 treated with 1 μM human S100A9 (light blue, outlined). There is no known agonist for zebrafish Tlr4bb and Tlr4al complexes. The negative control was vehicle treatment with 200 ng/uL Polymyxin B (PB) in PBS. All data was background subtracted and normalized to the signal from human TLR4 treated with endotoxin. Bars show the average signal across three biological replicates, with error bars indicating standard error. Statistics shown are p-values <0.05 from unpaired Welch t-tests.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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