Fig. 7

Correlation between echocardiographic parameters of LV remodelling and histological parameters measured by CardiLect Analyser after lectin histochemistry. (A) Rats were subjected to sham or TAC surgery. Echocardiography and lectin histochemistry were carried out after 14?16 weeks of follow-up. (B) Representative M-mode echocardiographic images of sham and TAC-operated animals after follow-up. (C) Echocardiographic parameters of LV remodelling showing increased LV mass and decreased systolic function after TAC surgery. *P < 0.05, unpaired t-test (n = 4 for sham, n = 7 for TAC groups; n represents the number of animals). (D) Cardiomyocyte cross-sectional area (CSA) and microvascular density (MVD), histological parameters of LV remodelling, were significantly altered after TAC surgery, as measured by CardiLect Analyser after lectin histochemistry. (E,F) CSA and MVD, as measured by CardiLect Analyser, significantly correlate with echocardiographic parameters of LV remodelling (P values represents statistical significance of Spearman's correlation test). CSA, cross-sectional area; EF, ejection fraction; FS, fractional shortening; LV, left ventricle; LVRi, left ventricular remodelling index; MVD, microvascular density; TAC, transverse aortic constriction.