PUBLICATION
Modularity of the segmentation clock and morphogenesis
- Authors
- Hammond, J.E., Baker, R.E., Verd, B.
- ID
- ZDB-PUB-250402-5
- Date
- 2025
- Source
- eLIFE 14: (Journal)
- Registered Authors
- Keywords
- agent-based models, evolution, evolvability, morphogenesis, physics of living systems, pre-somitic mesoderm, somitogenesis, zebrafish
- MeSH Terms
-
- Biological Clocks/physiology
- Computer Simulation
- Animals
- Embryonic Development
- Morphogenesis*
- Somites/embryology
- Mesoderm*/embryology
- Zebrafish*/embryology
- Models, Biological
- Body Patterning
- PubMed
- 40168062 Full text @ Elife
Citation
Hammond, J.E., Baker, R.E., Verd, B. (2025) Modularity of the segmentation clock and morphogenesis. eLIFE. 14:.
Abstract
Vertebrates have evolved great diversity in the number of segments dividing the trunk body, however, the developmental origin of the evolvability of this trait is poorly understood. The number of segments is thought to be determined in embryogenesis as a product of morphogenesis of the pre-somitic mesoderm (PSM) and the periodicity of a molecular oscillator active within the PSM known as the segmentation clock. Here, we explore whether the clock and PSM morphogenesis exhibit developmental modularity, as independent evolution of these two processes may explain the high evolvability of segment number. Using a computational model of the clock and PSM parameterised for zebrafish, we find that the clock is broadly robust to variation in morphogenetic processes such as cell ingression, motility, compaction, and cell division. We show that this robustness is in part determined by the length of the PSM and the strength of phase coupling in the clock. As previous studies report no changes to morphogenesis upon perturbing the clock, we suggest that the clock and morphogenesis of the PSM exhibit developmental modularity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping