FIGURE

Fig. 5

ID

ZDB-FIG-250401-27

Publication

Liang et al., 2024 - Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish

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Fig. 5

a The SH2EG59R fs/G59R fs embryos with Tg(cmcl2:mcherrry) background developed dilated atrium compared to those with normal cardiac morphology (SH2E+/+ or SH2E+/G59R fs) from the same SH2E+/G59R fs incross at 5 dpf. V, ventricle, A, atrium. b The SH2EG59R fs/G59R fs embryos developed thickened ventricle compared to those with normal cardiac morphology (SH2E+/+ or SH2E+/G59R fs) derived from the same SH2E+/G59R fs incross at 4 dpf. V, ventricle, A, atrium. c An inducible SH2E overexpression system driven by Hsp70L was constructed. d The Tg(fli1:egfp) background SH2E+/G59R fs incross embryos injected with SH2E overexpression plasmids were heat shocked at 48 hpf. 8 h later (56 hpf), ubiquitously expressed red fluorescent could be observed in the trunk. TP, transposase. e Inducible overexpression of SH2E resulted in stable reduction of PCE by about 6% in SH2E+/G59R fs incross at 5 dpf. UIC, uninjected control; TP, transposase; n = 3; **P < 0.01 compared with uninjected control. For (a, b, d), scale bars = 100 μm.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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