FIGURE

Fig. 4

ID

ZDB-FIG-250128-50

Publication

Lopes-Bastos et al., 2024 - The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma

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Fig. 4

Lack of telomerase leads to low proliferation and increased apoptosis, inflammation, and melanocyte differentiation (A) Principal-component analysis (PCA) based on untargeted transcriptomics data of tumors from 9-month-old fish. (B) Gene set enrichment analysis (GSEA) hallmarks of late-stage melanoma of tert−/− fish compared to tert+/+ highlighting inflammatory pathways, senescence, and melanocyte differentiation. (C–E) Representative immunofluorescence images and respective quantifications of tert+/+ and tert−/− tumors. Scale bars: 20 μm. (C) DNA damage by γH2AX, (D) proliferation by PCNA, and (E) apoptosis by cleaved caspase-3 immunofluorescence of 9-month-old fish tumors (n ≥ 4; unpaired t test). Error bars represent ± SEM; each dot represents an individual tumor; n ≥ 4; ∗p ≤ 0.05, ∗∗p ≤ 0.01, and ∗∗∗∗p ≤ 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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