FIGURE

Figure 3

ID

ZDB-FIG-250110-123

Publication

Widder et al., 2024 - Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach

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Figure 3

LPS concentration response curves for replicate tests during the optimization phase of assay development. The left graph depicts the percentage of fish with tail edema in response to increasing P. aeruginosa LPS concentrations. The right graph depicts the number of dead fish in response to increasing P. aeruginosa LPS concentrations. The goal was to determine a concentration that yielded close to 50% mortality while eliciting 100% combined tail edema and mortality in all fish. A concentration of 60 µg/mL of P. aeruginosa LPS was chosen for use in follow-on chemical screening.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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