FIGURE

Fig. 1

ID

ZDB-FIG-241230-39

Publication

Li et al., 2024 - Degarelix limits the survival of mycobacteria and granuloma formation

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Fig. 1

Degarelix limits mycobacterial survival and granuloma formation in zebrafish. (a) M. marinum burden distribution in wild-type zebrafish larvae treated with degarelix (1 ?M) or mock for 5 days. (b) Bacterial burden values in infected larvae treated with degarelix (1 ?M) or mock for 5 days. (c) Adult zebrafish were intraperitoneally infected with wild-type M. marinum/fish (400 CFU) for 2 weeks. Adults received oral degarelix (10 mg/kg/day) for 48 h before infection and for 14 days after. Bacterial burdens are shown (c). (d-f) Histopathology on whole fish sections using H&E or acid-fast staining at 14 dpi (scale bar = 20 ?m). Granulomas were compared between infected adult zebrafish treated with/without degarelix, and scored for <10 or >10 bacterial burden values (e) and necrotic granuloma percentages (f).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	bacterial treatment by injection: Mycobacterium marinum bacterial treatment by injection: Mycobacterium marinum, chemical treatment by environment: degarelix
Observed In:	granuloma formation
Stage:	Adult

Phenotype Detail

Acknowledgments

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