FIGURE

Fig. 5

ID

ZDB-FIG-241219-33

Publication

Zadmajid et al., 2024 - Testosterone acts through membrane protein GPRC6A to cause cardiac edema in zebrafish embryos

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Fig. 5

The testosterone phenotype in double mutants (gprc6a mosaic mutant+aruab142/uab142) is similar to that in the gprc6a mosaic mutant. One-cell stage aruab142/uab142 embryos were injected with Cas9 protein alone or together with a cocktail of four guide RNAs targeting different regions of the gprc6a gene. At 3 h post-fertilization, embryos were exposed to testosterone. Morphological phenotypes were assayed at 3 days post-fertilization. Each data point is the mean percentage of embryos in a single clutch exhibiting cardiac edema (19-80 embryos per clutch). Horizontal lines are the mean of each group. **P<0.01; ns, not significant (P>0.05); one-way ANOVA with Tukey's multiple comparisons test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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