FIGURE

FIGURE 6

ID

ZDB-FIG-241213-47

Publication

Chan et al., 2024 - Targeting TGF-β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica

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FIGURE 6

Alteration of mesenchymal stem cell subpopulations in Gorab^Prx1 mutant. (a) Number of Colony Formation Units (CFU) from the bone marrow stromal cells of 12 weeks old Control (N = 8), Gorab^Prx1 (N=) and Gorab^Prx1;Cdkn2a^Null (N = 8) mice. (b) Flow cytometry analysis of mesenchymal stem cells (mMSCs) defined as Lin‐ (CD45‐CD11b‐CD34‐Cd31‐) Sca‐1+. Flow cytometry analysis of mMSCs subpopulations as (c) mMSCs CD29+; (d) mMSCs CD44+; (e) mMSCs Cd51+ and (f) mMSCs CD140a+. N = 12 Control, N = 7 Gorab^Prx1, N = 8 Gorab^Prx1;Cdkn2a^Null. *p < 0.05, **p < 0.01, ***p < 0.001, ns, no statistically significant difference (unpaired Welch's t‐test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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