FIGURE

Fig. 4

ID

ZDB-FIG-241204-4

Publication

Burrows et al., 2024 - RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy

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Fig. 4

Adult C9orf72-ALS/FTD zebrafish show reduced swimming endurance. Kaplan–Meier analysis of swim tunnel performance in 6-month 12-month-old zebrafish. (A) The 2mer (Ctrl) zebrafish show no significant decline in swimming endurance between 6- and 12-month time points. Both (B) sense (S5) and (C) antisense (AS1) zebrafish lines significantly decline in swimming endurance between 6 and 12 months old. N = 9 2mer (Ctrl), N = 10 sense (S5) and N = 10 antisense (AS1). Log-rank (Mantel-Cox) test; *p < 0.05, **p < 0.01, ***p < 0.001. ALS = amyotrophic lateral sclerosis; FTD = frontotemporal dementia. [Color figure can be viewed at www.annalsofneurology.org]

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Ann. Neurol.