FIGURE

Fig. 2

ID

ZDB-FIG-241126-11

Publication

Yu et al., 2024 - Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish

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Fig. 2

The effects of Ponatinib on heart function of zebrafish larvae. (A) 1 dpf Tg (cmlc2: GFP) transgenic zebrafish were treated with 0.1 % DMSO or indicated concentrations of Ponatinib for 3 days. The represented images of Ponatinib-induced abnormal heart in 4 dpf zebrafish larvae. (B) SV-BA distance of 4 dpf zebrafish (n=8). Data are represented as mean � SEM. ***P < 0.005 vs. control group. (C) Atrial area of 4 dpf zebrafish (n=8). Data are represented as mean � SEM. *P < 0.05 and ***P < 0.005 vs. control group. (D) Ventricular area of 4 dpf zebrafish (n=8). Data are represented as mean � SEM. **P < 0.01 and ***P < 0.005 vs. control group. (E) Heart rate of 4 dpf zebrafish (n=10). Data are represented as mean � SEM. ***P < 0.005 vs. control group. (F) Ventricular fractional shortening of 4 dpf zenrafish (n=10). Data are represented as mean � SEM. *P < 0.05 and ***P < 0.005 vs. control group. (G) Representative images of apoptotic cells in the 4 dpf zebrafish heart as determined by TUNEL staining.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f1Tg (AB)
Condition:	chemical treatment by environment: ponatinib
Observed In:	atrium bulbus arteriosus cardiac muscle cell cardiac ventricle heart heart contraction sinus venosus
Stage:	Day 4

Phenotype Detail

Acknowledgments

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