FIGURE

Fig. 4

ID

ZDB-FIG-241111-42

Publication

Zhu et al., 2024 - Sex disparity in zebrafish liver cell proliferation after partial hepatectomy is regulated by sex hormone receptors and the S100A1-YAP signaling cascade

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Fig. 4

Effects of Yap1 inhibition on male zebrafish liver regeneration following PH. (A) Expression of ctgfa and cyr61 in dimethyl sulfoxide (DMSO)/verteporfin (VP)-pretreated male zebrafish livers at 6 h post-PH/sham surgery as determined by RT-qPCR. Each symbol represents one zebrafish. (B) IF staining of Pcna and Hnf4α in DMSO/VP-pretreated male zebrafish liver following PH or sham surgery. (C) Quantification of Pcna and Hnf4α double-positive proliferating hepatocytes based on B. Each symbol represents one zebrafish. (D) Changes in LBR of DMSO/VP-pretreated male LiPan zebrafish during PH-induced liver regeneration (n=3). Scale bar: 20 μm. ns, not significant (P>0.05); *P≤0.05, **P≤0.01, ****P≤0.0001 (two-tailed unpaired Student's t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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