FIGURE

Fig. 2

ID

ZDB-FIG-240903-116

Publication

Song et al., 2024 - Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage

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Fig. 2

Cone photoreceptors degenerate in 10 mpf adult irf8 mutants. (A?F) Immunohistochemistry with Zpr1 (magenta) and peanut agglutinin (PNA; yellow) on retinal cryosections from wild-type (A?C) and irf8 mutants (D?E) at 3 mpf, 6 mpf, and 10 mpf. (G) Quantification of Zpr1+ cell density in the dorsal retina of wild-type and irf8 mutants with age. (H) Quantification of PNA+ cone outer segments in the dorsal retina of wild-type and irf8 mutants with age. Data are plotted as means � SD and p-values were generated by Welch?s ANOVA test with Dunnett?s T3 multiple comparisons test (Zpr1) or an unpaired t-test (PNA). *p < 0.05, **p < 0.01. COS cone outer segments, ONL outer nuclear layer, INL inner nuclear layer, RGC retinal ganglion cell layer. Scale bar, 50 ?m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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