FIGURE

Fig. 1

ID

ZDB-FIG-240827-22

Publication

Unnikrishnan et al., 2024 - Gold(III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution

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Fig. 1

Alkenes as a transition-metal-mediated activating group. (a) (i) Allyl carbamate is a well-studied substrate with palladium (Pd) or ruthenium (Ru) as the catalyst. The activated alkene is attacked by an external nucleophile to eliminate a free amine. (ii) Pentenoic sec-amides are shown to form stable cyclized products with Ru photocatalysis. (b) Possibilities for an amide bond cleavage reaction via cyclization mechanism. The imine intermediate can be hydrolyzed after cyclization. Addition of a leaving group at the allyl position allows dual release of substrates possibly via β-elimination. (c) Design elements involved in the dual release strategy.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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