Fig. 8

(a) SEM analysis of hydrogel after lyophilization (scale 100 μm); SEM images of FL-cHy-NPs kept at (i) 25 °C, and (ii) 37 °C; SEM images of HK-cHy-NPs kept at (iii) 25 °C, and (iv) 37°C. (b) FE-SEM images analysis of cHy-NPs embedded hydrogel formulation by deep learning segmentation (scale 2.5 μm); Segmentation of FL-cHy-NPs at (i) 25 °C, and (ii) 37 °C; Segmentation of HK-cHy-NPs at (iii) 25 °C, and (iv) 37 °C. In each of these segmentations blue regions represent deep learning segmentation model identified as particles. (c) In vitro drug release study of (i) FL, and (ii) HK at 25 °C and 37 °C, respectivelyfor up to 696 h (29 days). (iii) The graph showing fitting of cumulative percent drug release (CPDR) of FL and HK release with the Korsmeyer-Peppas Model form the respective hydrogel formulation at 25 and 37 °C.