FIGURE

Fig. 5

ID

ZDB-FIG-240729-117

Publication

Brennan et al., 2024 - A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin

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Fig. 5

Oligodendrocyte precursors and myelin are unchanged in gphnbvo84/vo84 mutant spinal cord. A Representative in vivo images from Tg(olig1:mScarlet) and 3D reconstruction showing individual OPCs in the spinal cord of WT and gphnbvo84/vo84 at 5 dpf. B OPC number in 300-µm-length spinal cord from (A). nWT = 11 animals, ngphnb = 11 animals, 1 technical replicate, t[0.5192] df[20],. C Representative in vivo images of myelin in the dorsal spinal cord from Tg(mbp:GFP-CAAX) at body segment 7 (S7) and 15 (S15) of WT and gphnbvo84/vo84 at 5 dpf. D GFP signal intensity from (C). nWT = 8 animals, ngphnb = 11 animals, 1 technical replicate, F[3,, 33] = 0.6057. All data are represented as mean ± SEM; ns, not significant; (B) unpaired t-tests; (D) one-way ANOVA with Tukey’s post-hoc test

Expression Data

Genes:	mScarlet EGFP
Fish:	mitfa^w2/w2; ue2Tg (AB) mitfa^w2/w2; vo109Tg (AB) mitfa^w2/w2; gphnb^vo84/vo84; ue2Tg (AB) mitfa^w2/w2; gphnb^vo84/vo84; vo109Tg (AB)
Anatomical Terms:	spinal cord myelin sheath spinal cord oligodendrocyte
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; gphnb^vo84/vo84; ue2Tg (AB) mitfa^w2/w2; gphnb^vo84/vo84; vo109Tg (AB)
Observed In:	spinal cord myelin sheath spinal cord oligodendrocyte
Stage:	Day 5

Phenotype Detail

Acknowledgments

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