FIGURE

Fig. 8

ID

ZDB-FIG-240618-63

Publication

Sobah et al., 2024 - Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Model for the role of Stat3 in the development and function of neutrophils. Schematic representation of signaling downstream of Csf3r and Cxcr2. Activation of Csf3r by either Csf3a or Csf3b induces canonical activation of Stat3 to mediate primitive and definitive granulopoiesis and is negatively regulated by Socs3b. Non-canonical Stat3 stimulated by Csf3a induces transcription of cxcr2 to facilitate emergency granulopoiesis. Stimulation of Cxcr2 by Cxcl8b drives a positive feedback loop which increases transcription of cxcl8b to mediate neutrophil migration.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Innate Immun.