FIGURE

Figure 6.

ID

ZDB-FIG-240612-6

Publication

Rahmati et al., 2024 - Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay

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Figure 6.

NMD pathway in appb^−/−. A, Illustration of NMD pathway activation in appb^−/−. EJC, the exon-junction complex; PTC, premature termination codon. B, Relative appb mRNA expression levels in appb^−/− embryos injected with upf1MO (N = 12–15), upf2MO (N = 18–20), or upf3a/upf3bMO (N = 14–15) compared with uninjected appb^−/−. n = 3 biologically independent samples. Data shown as mean + SD. Student's two-tailed t test were used to calculate p values. *p < 0.05, **p < 0.01, ***p < 0.005, and ****p < 0.0001. ns, nonsignificant. Additional data relating to these analyses are provided in Extended Data Figure 6-1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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