FIGURE

Fig. 6

ID

ZDB-FIG-240603-9

Publication

Rinné et al., 2024 - Popeye domain containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5

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Fig. 6

Morpholino-mediated knock-down of popdc2 modifies embryonic cardiac action potential in the zebrafish heart (A) Representative voltage traces of cardiac action potentials in zebrafish embryos. POPDC2 MO: Morpholino-mediated knock-down of popdc2. hpf: hours postfertilization. (B–D) Analysis of (B) action potential frequency, (C) APD50, and (D) APD90. The number of biological replicates is indicated in bar graphs. Data are presented individually but also as mean ± s.e.m. (E) Representative voltage traces of cardiac action potentials in embryonic zebrafish focusing on the fast depolarization phase. (F) Analysis of the action potential overshoot. The number of biological replicates is indicated in bar graphs. Data are presented individually but also as mean ± s.e.m. Significance was probed using a two-sided Student’s t test. ∗∗, p < 0.01. (G) Analysis of the action potential upstroke velocity. The number of biological replicates is indicated in the individual bar graphs. Data are presented individually but also as mean ± s.e.m. Significance was probed using a two-sided Student’s t-test. ∗, p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO3-popdc1
Knockdown Reagent:	MO3-popdc1
Observed In:	cardiac muscle cell cardiac muscle cell action potential
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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