FIGURE

Fig. 6

ID

ZDB-FIG-240510-26

Publication

Yang et al., 2024 - Pcgf5: An important regulatory factor in early embryonic neural induction

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Fig. 6

Knockdown of pcgf5a expression results in abnormal early embryonic development in zebrafish. (A-C) qPCR and Real-time PCR was used to detect the expression of pcgf5a and pcgf5b in zebrafish embryos at different periods, from the 1-cell stage to 24 hpf. (D) A dose-dependent statistical graph of the embryo phenotype, and 7 ng MO was selected as the appropriate injection dose. (E) The phenotypes of zebrafish embryos taken under light microscope at 16 hpf and 24 hpf stage. Red markers show that the brain size of the pcgf5a-deficient zebrafish embryos is obviously smaller, and white markers show that the eye vesicles of the pcgf5a-deficient zebrafish embryos are smaller and the eye morphology is abnormally developed. Scale bar, 50 μm.

Expression Data

Genes:	pcgf5a pcgf5b
Fish:	WT
Anatomical Term:	whole organism
Stage Range:	1-cell to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-pcgf5a
Knockdown Reagent:	MO1-pcgf5a
Observed In:	brain eye
Stage Range:	14-19 somites to Prim-5

Phenotype Detail

Acknowledgments

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