FIGURE

Fig. 7

ID

ZDB-FIG-240402-12

Publication

Liang et al., 2024 - A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration

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Fig. 7

csrp3 overexpression relieves the inhibitory effects of multiple signaling blockage on zebrafish heart regeneration. A, B Comparative analysis of the expression changes of GFP in ablated + /218A hearts and endogenous csrp3 in ablated wild-type hearts after inhibiting blood flow (tricaine), Notch (DAPT), and ErbB (AG1478) signaling. Scale bars, 20 μm. C Fluorescence pattern of Tg(cmcl2:Csrp3-EGFP) at 4 dpf. Scale bars, 20 μm. D Confocal images showed that Csrp3 overexpression (OE) ameliorated the impairment of heart regeneration resulting from inhibiting blood flow (tricaine), Notch (DAPT), and ErbB (AG1478) signaling. Scale bars, 20 μm. E Quantification of the regeneration ratio of ablated wild-type and Csrp3 overexpressed larvae after treatment with indicated inhibitors at 4 dpa/7 dpf. N = 481, 548, 487, 411, 689, 524, 312, 328, respectively. Data are presented as mean ± SD, Student’s t-test, **P < 0. 01, ***P < 0.001, ****P < 0.0001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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