Fig. 5
- ID
- ZDB-FIG-240321-7
- Publication
- Hodorovich et al., 2024 - Effects of 4 Testing Arena Sizes and 11 Types of Embryo Media on Sensorimotor Behaviors in Wild-Type and chd7 Mutant Zebrafish Larvae
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Medium type impacts behavioral phenotype penetrance in chd7 mutants. (A) Acoustic startle responses, average SLC frequency of chd7+/+ and chd7ncu101/ncu101 treated in 1 × E3 (chd7+/+ n = 18, chd7ncu101/ncu101 n = 15) or 1 × E3 with methylene blue (chd7+/+ n = 18, chd7ncu101/ncu101 n = 14) (mean ± SEM). (B) Normalized SLCs and (C) LLCs (AU), calculated by the area under the SLC or LLC frequency curves, respectively, for individual larvae, normalized to chd7+/+ [1 × E3]. Asterisks represent statistical significance for chd7ncu101/+, ncu101/ncu101 compared to wild-type siblings within medium type (1 × E3: chd7+/+ n = 18, chd7ncu101/+ n = 25, chd7ncu101/ncu101 n = 15; 1 × E3 MB: chd7+/+ n = 18, chd7ncu101/+ n = 38, chd7ncu101/ncu101 n = 14; 1 × E2: chd7+/+ n = 20, chd7ncu101/+ n = 36, chd7ncu101/ncu101 n = 11; 1 × E2 MB: chd7+/+ n = 13, chd7ncu101/+ n = 33, chd7ncu101/ncu101 n = 18; Hank's: chd7+/+ n = 18, chd7ncu101/+ n = 33, chd7ncu101/ncu101 n = 17). (D) Spontaneous locomotion, sum of total distance traveled, normalized to chd7+/+ [1 × E3], (E) swim and (F) turn frequencies for individual larvae. Asterisks represent statistical significance for chd7ncu101/+, ncu101/ncu101 compared to wild-type siblings within medium type (1 × E3: chd7+/+ n = 18, chd7ncu101/+ n = 26, chd7ncu101/ncu101 n = 17; 1 × E3 MB: chd7+/+ n = 18, chd7ncu101/+ n = 38, chd7ncu101/ncu101 n = 14; 1 × E2: chd7+/+ n = 21, chd7ncu101/+ n = 38, chd7ncu101/ncu101 n = 11; 1 × E2 MB: chd7+/+ n = 13, chd7ncu101/+ n = 26, chd7ncu101/ncu101 n = 20; Hank's: chd7+/+ n = 18, chd7ncu101/+ n = 33, chd7ncu101/ncu101 n = 18) (mean ± SD, One-way ANOVA with Student's t each pair test for multiple comparisons, *p < 0.05, **p < 0.01). |