FIGURE

Figure 1

ID

ZDB-FIG-240214-1

Publication

Witkamp et al., 2024 - Lithium: effects in animal models of vanishing white matter are not promising

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Figure 1

Simplified schematic overview of lithium effects on GSK3β, eIF2B, and β-catenin. Lithium inhibits GSK3β activity. GSK3β inhibition lowers eIF2B phosphorylation (yellow) levels resulting in increased eIF2B activity and presumably downregulated expression of ATF4 and the ATF4-regulated transcriptome. GSK3β inhibition also stabilizes β-catenin by impeding its phosphorylation (yellow) at Ser33, Ser37, and Thr41. Phosphorylated β-catenin is highly unstable and was therefore not quantified. Non-phosphorylated β-catenin moves to the nucleus and joins with a member of the T-cell factor/lymphoid enhancer factor (TCF/LEF) family of transcription factors. This joining upregulates the expression of several genes, including EphB, Sox9, and Axin2. ➔ indicates stimulation; --| indicates inhibition. The image was created with BioRender.com.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.