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Dorrity et al., 2023 - Proteostasis governs differential temperature sensitivity across embryonic cell types

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Fig. 1

Effects of stress on phenotypic variability are captured via individual animal hashing of single-cell transcriptomes (A) Representative images of 24 hpf embryos raised at standard and elevated temperature; individual embryos with normal-looking and bent-tail phenotypes were included in the dataset. (B) Experimental workflow for temperature perturbation experiment and individual embryo hashing. (C) Uniform manifold approximation and projection (UMAP) of temperature-perturbation dataset, projected into coordinate space of reference atlas (see Saunders et al.32). Right side shows how single-cell data are transformed to generate cell composition matrices.

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Reprinted from Cell, 186, Dorrity, M.W., Saunders, L.M., Duran, M., Srivatsan, S.R., Barkan, E., Jackson, D.L., Sattler, S.M., Ewing, B., Queitsch, C., Shendure, J., Raible, D.W., Kimelman, D., Trapnell, C., Proteostasis governs differential temperature sensitivity across embryonic cell types, 50155027.e125015-5027.e12, Copyright (2023) with permission from Elsevier. Full text @ Cell