FIGURE

Figure 6

ID

ZDB-FIG-240206-64

Publication

Özcan et al., 2024 - Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance

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Figure 6

Intraventricular injection of P3 decreases sleep and shortens sleep bout lengths

Exemplar 24 h traces of the average waking activity of WT larvae injected with either P3 or vehicle control on a 14h:10h light:dark cycle. Shown is a single exemplar experiment.

(B and C) Average waking activity during the day (B) and night (C) across three independent experiments. Each dot represents a single larva normalized to the experiment-matched WT mean. The bars represent the mean.

(D) Exemplar 24 h trace of the average sleep for the experiment shown in (A).

(E) Day sleep, (F) night sleep, (G) day sleep bout length, (H) night sleep bout length, (I) day sleep bout number, and (J) night sleep bout number. n = the number of larvae. ^nsp > 0.05, ∗p ≤ 0.05, ∗∗p ≤ 0.01, Kruskal-Wallis, Tukey’s post hoc test. n = number of larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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