FIGURE

Fig. 8

ID

ZDB-FIG-240201-39

Publication

Sri Hari et al., 2023 - Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability

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Fig. 8

Dimercaprol treatment significantly decreases a series of ‘seizure-like’ parameters in DS (scn1Lab) mutants. DS mutants were treated with 100 μM dimercaprol for 4 h. Dimethyl sulfoxide (DMSO, < ∼1%) was used as vehicle control. 10 μM stiripentol (STP), and 10 μM PK11195 were used as positive controls. (A) No. of spikes, (B) Mean spike rate, (C) Number of electrographic burst events, (D) Electrographic burst frequency, and (E) Synchrony index were assessed by the Axion MEA system. The minimum threshold value for all parameters was set to be greater than 3% to be considered a reliable/true signal. Data are represented as mean ± SEM (error bars). **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: not significant versus vehicle control by one-way ANOVA with Dunnett's post-hoc test. n = 3–5 larvae/grp. N = 10 experimental replicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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