FIGURE

Fig. 1

ID

ZDB-FIG-240130-8

Publication

Darrah et al., 2023 - Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism

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Fig. 1

Following enzyme-mediated hydrolysis of the β-lactam ring by β-lactamase (PDB ID 4F6H), the resulting amine intermediate undergoes self-immolation. The release of the 5′-end generates the active, linearized MO capable of hybridizing to its respective target mRNA and silencing gene expression.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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