FIGURE

Fig. 9

ID

ZDB-FIG-240125-120

Publication

Pellegrini et al., 2023 - Estrogenic regulation of claudin 5 and tight junction protein 1 gene expression in zebrafish: A role on blood-brain barrier?

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Fig. 9

Aromatase B-positive radial glial cells strongly interact with endothelial cells being able to take up high-density lipoproteins (HDLs). (a?c) Aromatase B immunohistochemistry (red) in Tg(fli1a:EGFP)y1 fish in which endothelial cells express GFP (green) showing strong interactions between neural stem cells and blood vessels in the ventral nucleus of the ventral telencephalon (Vv) and the dorsomedial region (Dm) of the telencephalon. (d?g) Intraperitoneal injection of HDLs in zebrafish allowed HDL uptake by cerebral endothelial cells as revealed by ApoA1 immunohistochemistry (red) in Tg(fli1a:EGFP)y1 fish (green) as shown in these transversal sections of two cerebral blood vessels. (h) Intraperitoneal injection of HDLs in Tg(cyp19a1b:GFP) showing ApoA1 (red) proximity with AroB-positive neural stem cell endfeets along a sagittal blood vessel section in the telencephalon. Tg(cyp19a1b:GFP) zebrafish expressed GFP in radial glial cells (RGCs) (Tong et al., 2009). Scale bar: 21 ?m (a?b), 14 ?m (c?g), and 3.5 ?m (h).

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Comp. Neurol.