FIGURE

Fig. 7

ID

ZDB-FIG-231030-147

Publication

Gao et al., 2023 - A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline

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Fig. 7

Compounds increased glucose uptake without any apparent toxicity: (A) The β-cell number of each compound-treated double transgenic zebrafish Tg(−1.2ins:htBid^TE-ON; LR) Tg(−1.2ins:H2Bmcherry). Total of 10 μM of each compound was added at 5 dpf after the β-cell ablation for 24 h. (B) The glucose uptake indicated by 2-NBDG fluorescence. The larvae of each group were induced with doxycycline and tebufenozide except the group of tBid in 3 dpf for 48 h. Total of 10 μM of each compound was added at 5 dpf after the β-cell ablation for 24 h. Then, 2-NBDG was incubated for 3 h in dark. RGZ: rosiglitazone. The values shown are means ± SEM from three independent experiments. * p < 0.05, ** p < 0.01 and *** p < 0.001 via one-way ANOVA. (C) Morphology of 24 hpf embryos or 72 hpf zebrafish larvae treated with compounds. (D) Blood vessel morphology of 6 dpf zebrafish larvae Tg(flil:eGFP) treated with compounds.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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