FIGURE

Fig. 4

ID

ZDB-FIG-230925-12

Publication

Dal Forno et al., 2023 - Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions

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Fig. 4

Toxicity of Propargyl-Lap (2) compared to ?-lapachone for cancer cell lines measured by CellTiter Blue assay. (A) SKBR3 cell viability for 72 h. (B) Cell viability of SKBR3 cells after treatment with Propargyl-Lap (2) and subsequent decaging efficiency upon treatment with Pd(0)-NPs or PdI₂-NPs, after 72 h (C) MOLM13 cell viability for 48 h. (D) Cell viability of MOLM13 cells after treatment with Propargyl-Lap (2) and subsequent decaging efficiency upon treatment with PdI₂-NPs, after 48 h. Cell viability was determined by CellTiter Blue assay. The statistical significance: **P ? 0.01, ***P ? 0.001, and ****P ? 0.0001. Each experiment was performed in technical triplicates and two biological experiments. Error bars represent the standard error of the mean. Cells were treated with increasing concentrations of 2 and ?-Lap during 48 h, after which the cell viability was determined using the CellTiter Blue assay. IC₅₀ values were calculated from the generated eight-point semilog dose?response curves.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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