FIGURE

Fig. 2

ID

ZDB-FIG-230920-21

Publication

Styrkarsdottir et al., 2023 - Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect

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Fig. 2

Loss of bmp6 causes erosive-like phenotypes in the zebrafish vertebral precursors. (A–C’). Analysis of cartilage (blue) and bone (red) in the vertebral column of 14 days post fertilisation wild-type (WT) and bmp6^+/- zebrafish larvae. (A, A’) WT larvae have a normally segmented and ossified centra (vertebral precursors) and neural (na) and hemal arches (ha), whereas (B, C’) bmp6^+/ ⁻ have multiple defects, including bone erosions (arrow in B and B’), structural defects in the centra (arrowhead in B, C and C’), ectopic cartilage formation (arrow in C’), and disruptions in the neural and hemal arches (asterisks in C’). No defects are observed in the cartilaginous structures of the fins. All images are lateral views with anterior to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmp6^z52/+ (TU)
Observed In:	centrum hemal arch neural arch vertebra cartilage tissue
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Ann. Rheum. Dis.