FIGURE

Fig. 6

ID

ZDB-FIG-230904-6

Publication

Bi et al., 2023 - Polysarcosine-based lipid formulations for intracranial delivery of mRNA

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Fig. 6

Biodistribution of lipoplexes composed of fluorescently labeled liposomes (megenta, DOTAP/DOPE/DSPE-Rhodamine /C14-pSar2k at a molar ratio of 48.65/48.65/0.2/2.5, 30 mM) and Atto488 labeled luciferase mRNA (green, 150 pg mRNA, N/P 10) (A) in brain after intraventricular injection and (B) in whole embryo after intravenous injection in 2.5 dpf ABTL zebrafish embryos. Confocal images were taken by 10× lens for whole embryos view (scale bar: 100 μm) and 40× lens (scale bar: 20 μm) at 1 hpi, 2 hpi, 4 hpi and 24 hpi. Co-localized liposomes and mRNA were shown in red square. Free liposomes were marked by orange arrows in the zoomed images, respectively. F: forebrain; M: midbrain; H: hindbrain. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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