FIGURE
Fig. 8
- ID
- ZDB-FIG-230816-14
- Publication
- Légaré et al., 2023 - Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response
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Fig. 8
Several markers of the mitochondrial stress response are upregulated in our double chchd10−/− and chchd2−/− model at 5 dpf. (a) All mitochondrial integrated stress response (mt-ISR) upstream activators were significantly increased in the double chchd10−/− and chchd2−/− model including atf4a (p = .019); atf4b (p = .01); atf5a (p = .0001); atf5b (p = .0014); chop (p = .0029). (b) Several downstream targets are upregulated in the double chchd10−/− and chchd2−/− model including htra2 (p = .0002); fgf21 (p = .0062), but not clpp (p = .1799). (c) Oxygen responsive transcript cox4i2a was significantly increased in our double chchd10−/− and chchd2−/− model (p = .017). Data is represented as mean ± SEM. Sample sizes (n) are noted in parentheses. Significant differences from wild type larvae are represented by either a single asterisk (p < .05) or double asterisk (p < .01) using a one-way ANOVA followed by a Tuckey's multiple comparison test.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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