FIGURE

Fig. 4

ID

ZDB-FIG-230704-4

Publication

McKeown et al., 2022 - Pilot Study of Jadomycin B Pharmacokinetics and Anti-Tumoral Effects in Zebrafish Larvae and Mouse Breast Cancer Xenograft Models

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Fig. 4

Jadomycin B reduced 4T1 primary tumor growth. Adult female Balb/C mice were injected with 100 000 4T1 cells into the fourth mammary fat pad on day 0, followed by jadomycin B (Jad B) treatment (12 mg/kg every 12 h) from day 6 to 15 after tumor cell implantation. Tumor volumes were measured every 2 days (A). At the study endpoint, tumors were excised and weighed (B) and the number of lung metastasis were determined by the 6-thioguanine colony forming assay (C). The data in panel A are shown as mean � SEM (n = 8). ^***P ? 0.001, compared to the respective vehicle control, as determined by a two-way repeated measures ANOVA, with Bonferroni multiple comparison test. The data in panels B and C are shown as scatter plots with mean � SEM. The groups were compared using a non-parametric Mann?Whitney test.

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