FIGURE

Figure 3

ID

ZDB-FIG-230613-13

Publication

Xi et al., 2023 - Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish

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Figure 3

glut2-deletion results in impaired glucose uptake in MZglut2 fish. (A) Glucose content in the blood of the control and MZglut2 fish (n = 12). (B) Glucose content in the muscle of the control and MZglut2 fish (n = 8). (C) Glucose content in the liver of the control and MZglut2 fish (n = 8). (D) The hepatic glucose uptake levels (2-DG) of the control and MZglut2 fish (n = 20). (E) Blood glucose levels of the control and MZglut2 fish after the glucose tolerance test for 20, 40, 60, 80, 100, and 120 min (n = 6). (F) Blood glucose levels of the control and MZglut2 fish after being fed a high carbohydrate diet for 0, 1, 2, 3, 4.5, 6, and 8 h (n = 6). (G) Transcriptional expression of glut2, glut1, glut3, glut5, glut8, glut9, glut12, and sglt1 in the intestine of the control and MZglut2 fish after fed high carbohydrate diet at 2 h (n = 6). (H) Transcriptional expression of glut2, glut1, glut3, glut5, glut8, glut9, glut12, and sglt1 in the liver of the control and MZglut2 fish after fed high carbohydrate diet at 2 h (n = 6). A two-tailed unpaired t-test was used to detect significance. ****P < 0.0001. ***P < 0.001. **P < 0.01. *P < 0.05. ns, no significance.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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