FIGURE

Figure 4

ID

ZDB-FIG-230529-64

Publication

Widelski et al., 2023 - Simple Coumarins from Peucedanum luxurians Fruits: Evaluation of Anxiolytic Activity and Influence on Gene Expression Related to Anxiety in Zebrafish Model

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Figure 4

The effects of officinalin isobutyrate (1.5, 3, 6, 9, 15, and 30 µM) and diazepam (DZ, 10 µM) on locomotor activity during all three light–dark challenge phases. (A) Average distance moved by zebrafish larvae within each 1 min time bin under either light (open bars) or dark (filled bars). (B) The percentage of distance moved by zebrafish larvae in the central area during the light phase (white bars) or dark phase (filled bars). (C) The percentage of time spent by zebrafish larvae in the central area during the light phase (white bars) or dark phase (filled bars). Data are presented as mean ± SEM; n = 32. * p < 0.05, ** p < 0.01, *** p < 0.001 in comparison to light conditions within the same concentration group; ^ p < 0.05, ^^ p < 0.01, ^^^ p < 0.001 in comparison to control group under dark condition; # p < 0.05; ## p < 0.01 in comparison to control group under light condition (post hoc Bonferroni’s test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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