FIGURE

Fig. 2

ID

ZDB-FIG-230516-21

Publication

Chen et al., 2022 - TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Tgs1 overexpression ameliorates the wing expansion defects caused by neuronal knockdown of Smn in Drosophila. (A) Examples of flies showing wing expansion failure upon nsyb-GAL4-driven (neur>) Smn RNAi. (B) Frequencies of the defective wing expansion phenotype in flies co-expressing a UAS-Smn RNAi (Smn RNAi) construct and the indicated UAS constructs driven by nsyb-GAL4 (neur>). UAS dTgs1 encodes GFP-tagged dTgs1; UAS hTGS1 encodes GFP-tagged human TGS1; UAS CTR is a control construct expressing the unrelated Mst protein. ΔSmn/+ flies are heterozygous for a deficiency of the Smn locus. Error bars: ± SEM. Numbers within and next to bars are the animals tested. P-values: one-way ANOVA with Tukey's multiple comparisons test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.