FIGURE

Figure 2

ID

ZDB-FIG-230430-10

Publication

Liang et al., 2023 - Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling

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Figure 2

The embryos with nop56 deficiency display morphological abnormalities due to increased apoptosis. (A–H) The phenotypes of wildtype siblings and nop56^−/− mutants. At 24 hpf (A,B), a minor curved tail (arrowhead) and slightly slower development were seen in the mutants. At 36 hpf (C,D), the ventricle and cerebellum of the mutants showed obvious bulging, and malabsorption of the yolk led to a slight swelling of the yolk sac, and pigmentation was delayed. The narrow eyes and edema in the heart were more apparent at 48 hpf (E,F). At 72 hpf (G,H), the mutants showed cardiac edema, a severely deformed trunk and yolk, and a smaller head and eyes. (I–P) The apoptosis level of the siblings and mutants at 24 hpf (I,J), 30 hpf (K,L), 36 hpf (M,N), and 48 hpf (O,P), determined using TUNEL staining. The arrowhead indicates apoptotic signals. All scale bars represent 500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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